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Total Synthesis of (−)-FR901483

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NIAID Data Ecosystem2026-03-07 收录
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A total synthesis of the immunosuppressive alkaloid (−)-FR901483 (1) has been described. The intriguingly azatricyclic structure of 1 was constructed by the semipinacol-type rearrangement and intramolecular Schmidt reaction of an azido cyclohexanone derivative. This strategy provides a distinctive and competitive approach to the natural product 1.

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2012-07-20
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