Latency to fall in rotarod task for mice tested with various inhibition of cerebellar nuclei neurons and corresponding control groups

This dataset represents the latency to fall in fixed-speed and accelerating rotarod tasks in mice. The accelerating rotarod protocol is conducted over 7 days, with 7 trials per day for each mouse. In the fixed-speed rotarod protocol, each mouse is exposed to each speed once.
Two sets of experiments are included. In the first set, mice receive either sham or adeno-associated virus (AAV) bilateral injections into the cerebellar nuclei (CN) to express an genetically engineered receptor (Designer Receptor Exclusively Activated by Designer Drugs or \"DREADD\") inhibiting the neurons when activated by the synthetic molecule (clozapine-N-oxyide, CNO). Mice in both the sham and DREADD groups perform the rotarod task either with CNO or saline administered during the 7 days of training, or with CNO/saline administered after each session to assess effects on the overnight consolidation of the learning that took place within each day.
In the second set of experiments, the effect of selective inhibiti..., , # Latency to fall in rotarod task for mice tested with various inhibition of cerebellar nuclei neurons and corresponding control groups

Dataset DOI: [10.5061/dryad.51c59zwpw](https://doi.org/10.5061/dryad.51c59zwpw)

## Description of the data and file structure

The files contain the latency to fall which characterizes the performance of mice on the accelerating rotarod for different groups of mice receiving different sort of inhibition of the cerebellar nuclei neurons while, or just after, they undergo 7 trials of accelerating rotarod trial. The groups of mice are described in the publication Varani et al. Elife 2026.
### Files and variables

#### File: all_groups_fixed_speed_rotarod_latency2fall.csv

**Description:** Performance of different groups of mice exposed to 4 different fixed speed rotarod. This is a control experiment to test that mice are able to run normally on the rotarod under the different sorts of treatments.

##### Variables

* Latency to fall presented with 1 colum..., ,