A Diverted Total Syntheses of Potent Cell Adhesion Inhibitor Peribysin E Analogues

Preliminary results from a program aimed at the creation of a focused library of analogues around the natural product peribysin E, a potent biologically active and structurally fascinating molecule, are reported. The total synthesis of (±)-peribysin E was accomplished using a short route. Eight new analogues of the natural compound have been accomplished by means of “diverted total synthesis” in less than 10 steps. The present effort highlights protecting-group-free total syntheses and the shortest route to access these functionally embellished hydrindanes.