five

eATP-responsive synthetic yeast ameliorate TNBS-induced colitis

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NIAID Data Ecosystem2026-03-12 收录
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE152869
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By combining directed evolution and synthetic biology, we engineered novel synthetic yeasts probiotics for the dynamic modulation of intestinal inflammation. In this experiment we treated TNBS-colitis induced mice with these probiotics and test the amelioration of immune response in the transcriptional level in the colon. A colon piece was colected from each mouse at the peak of the diesease for transcriptional analysis. Control groups were included.
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2021-04-24
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