Exercise-induced methylation of the Serhl2 promoter and implication for lipid metabolism in rat skeletal muscle

DNA methylation is an epigenetic mark that influences cell programming and function. Environmental factors such as physical activity alter DNA methylation, with exercise-responsive methylation changes in various tissues including skeletal muscle. Overall design: We used whole-genome methylated DNA immunoprecipitation (MeDIP) sequencing to determine the skeletal muscle DNA methylation signature in response to endurance swim training.