Leishmania major N-myristoyltransferase in complex with a hybrid inhibitor (compound 45).

Leishmania major N-myristoyltransferase in complex with a hybrid inhibitor (compound 45). Descriptor: GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE, MAGNESIUM ION, N-{2-chloro-5-[(3S,4R)-1-[(3R)-4-(4-chlorophenyl)-3-hydroxybutanoyl]-4-(hydroxymethyl)pyrrolidin-3-yl]phenyl}-2-(4-fluorophenyl)acetamide, ... Authors: Hutton, J.A, Goncalves, V, Brannigan, J.A, Paape, D, Waugh, T, Roberts, S.M, Bell, A.S, Wilkinson, A.J, Smith, D.F, Leatherbarrow, R.J, Tate, E.W. Deposit date: 2014-04-14 Release date: 2014-10-01 Last modified: 2024-05-08 Method: X-RAY DIFFRACTION (1.65 Å) Cite: Structure-Based Design of Potent and Selective Leishmania N- Myristoyltransferase Inhibitors. J.Med.Chem., 57, 2014硕大利什曼原虫（Leishmania major）N-肉豆蔻酰基转移酶与杂合抑制剂（化合物45）的复合物结构。数据集描述符：甘氨酰肽N-十四烷酰基转移酶（GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE）、镁离子（MAGNESIUM ION）、N-{2-氯-5-[(3S,4R)-1-[(3R)-4-(4-氯苯基)-3-羟基丁酰基]-4-(羟甲基)吡咯烷-3-基]苯基}-2-(4-氟苯基)乙酰胺，…… 作者：Hutton, J.A、Goncalves, V、Brannigan, J.A、Paape, D、Waugh, T、Roberts, S.M、Bell, A.S、Wilkinson, A.J、Smith, D.F、Leatherbarrow, R.J、Tate, E.W。保藏日期：2014-04-14；发布日期：2014-10-01；最后修改日期：2024-05-08。实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率1.65埃（Å）。引用文献：《基于结构设计的强效选择性硕大利什曼原虫N-肉豆蔻酰基转移酶抑制剂》，《药物化学杂志》（J.Med.Chem.），第57卷，2014年