Type I Interferons (IFN-I) stimulate pro-inflammatory programs critical for immune activation, but also induce immune-suppressive feedback circuits that contribute to the failure of cancer control. Ye

NIAID Data Ecosystem20

Additional file 2 of Investigation of reversible histone acetylation and dynamics in gene expression regulation using 3D liver spheroid model

组蛋白乙酰化

3D肝脏模型基因表达

Additional file 2. Protein Coding Time-course analysis

Figshare2022-11-21 更新10

Methamphetamine administration causes differential alterations in gene expression and dynamic patterns of histone acetylation/hypoacetylation in the rat nucleus accumbens

甲基苯丙胺成瘾

组蛋白乙酰化

Methamphetamine (METH) addiction is associated with a plethora of neuropsychiatric symptoms. In rodents, administration of the drug is accompanied by complex changes in gene expression in the dorsal s

NIAID Data Ecosystem30

Single cell RNAseq of Wild Type and IL27ra KO Tumor infiltrating lymphocytes isolated from B16F10 melanoma batch 1. Single cell RNAseq of Wild Type and IL27ra KO Tumor infiltrating lymphocytes isolated from B16F10 melanoma batch 1

单细胞免疫组学

T细胞耗竭

Expression of co-inhibitory receptors, such as CTLA-4 and PD-1, on effector T cells is a key mechanism for ensuring immune homeostasis. Dysregulated co-inhibitory receptor expression on CD4+ T cells p

NIAID Data Ecosystem20

ChIP-seq analysis of exhausted T cells with or without PAC1

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