Toward Overcoming Pyrethroid Resistance in Mosquito Control: The Role of Sodium Channel Blocker Insecticides

The 3D coordinates of sodium channel models and docked insecticides in the Protein Data Bank (PDB) file format:The inactivated-state model of Anopheles gambiae voltage-gated sodium channel (built on the template of human Nav1.7 structure, PDB code: 6j8g): agnav_h7_H.pdbThe open-state model of Anopheles gambiae voltage-gated sodium channel (built on the template of rat Nav1.5 structure, PDB code: 7fbs): agnav_open_H.pdbDocking positions of sodium channel blocker insecticides, DCJW and metaflumizone, in the inactivated-state and open-state models of AgNav1 channel: agnav_h7_DCJW.pdb ; agnav_h7_metaflumizone.pdb ; agnav_open_DCJW.pdb ; agnav_open_metaflumizone.pdbDocking positions of pyrethroid insecticide, etofenprox, in the inactivated-state and open-state models of AgNav1 channel: agnav_h7_etofenprox.pdb, agnav_open_etofenprox.pdbThe bottleneck radius distributions of the four lateral fenestrations in the inactivated state model of the mosquito sodium channel calculated using CAVER3.0 based on three 250 ns-long molecular dynamics trajectories combined: BR_DI-DIIfen.txt ; BR_DII-DIIIfen.txt ; BR_DIII-DIVfen.txt ; BR_DIV-DIfen.txt