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Synthesis of Highly Functionalized Bicyclo[<i>m</i>.<i>n</i>.1]alkanones via a Cationic Reaction Cascade

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NIAID Data Ecosystem2026-03-06 收录
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The acid-mediated Prins/pinacol and the triple domino reactions Diels−Alder/Prins/pinacol were used to construct highly functionalized bicyclo[m.n.1]alkanones 19−29 and 33a−c possessing various ring sizes from ketals 8−18 and 31a−c in 44−96% yields. This approach proves to be highly efficient and reliable to generate high molecular complexity in a single step.

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2016-05-05
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