The in situ detection of caspase-3 activity has applications in the imaging and monitoring of multiple pathologies, notably cancer. A series of cell penetrating FRET-based fluorogenic substrates were
b, VPA- or TSA-treated groups differ significantly from their respective controls (zero, a) at the P 0.05 level (Mann-Whitney test); TSA, trichostatin A; VPA, valproic acid; n, 1000 cells per experime
Cells (2×10 5 ) were cultured in 6-well plates, and then were incubated with sunitinib for 24 hr. Necrosis was analyzed using the Annexin V-FITC/PI Apoptosis Detection Kit (40302ES50, Yeasen
