Rho

Predicted to enable 11-cis retinal binding activity; G protein-coupled photoreceptor activity; and spectrin binding activity. Involved in photoreceptor cell maintenance. Acts upstream of or within several processes, including podosome assembly; rod bipolar cell differentiation; and thermotaxis. Located in several cellular components, including rod photoreceptor outer segment; sperm head plasma membrane; and sperm midpiece. Is expressed in several structures, including brain; eye; and heart. Used to study congenital stationary night blindness autosomal dominant 1; retinitis pigmentosa; and retinitis pigmentosa 4. Human ortholog(s) of this gene implicated in congenital stationary night blindness autosomal dominant 1; fundus albipunctatus; night blindness; retinitis pigmentosa; and retinitis pigmentosa 4. Orthologous to human RHO (rhodopsin). [provided by Alliance of Genome Resources, Nov 2024]

预测该基因可激活11-顺式视黄醛结合活性；G蛋白偶联光感受器活性；以及层粘连蛋白结合活性。参与光感受器细胞的维持。在包括泡状体组装；杆状体双极细胞分化；以及趋热性在内的多个过程中发挥上游作用或作用其中。位于多个细胞成分中，包括杆状体光感受器外节；精子头质膜；以及精子中部。在包括大脑；眼睛；和心脏在内的多个结构中表达。用于研究常染色体显性遗传性静止性夜盲症1；色素性视网膜炎；以及色素性视网膜炎4。与常染色体显性遗传性静止性夜盲症1；白点眼底；夜盲症；色素性视网膜炎；以及色素性视网膜炎4相关的人类同源基因。与人类RHO（视紫红质）同源。[由基因组资源联盟提供，2024年11月]