Proteins with pQTL variants and their association with AD PRS.

pQTL- AD PRS assocation was ascertained in a linear regression model with AD PRS as the outcome and pQTL, age, sex, and principal components as covariates. Beta represents the average change in AD PRS for a 1 unit change in pQTL variant where the pQTL variant is encoded as 0,1,2. A P value < 0.05/14, where 14 is the number of unique pQTL variants, was considered significant. pQTL variants within 1Mb of an aptamer were considered as cis-pQTL with remaining variants being trans-pQTLs. A P value < 0.05/14, where 14 is the number of unique pQTL variants considered, was considered significant.”
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