Crystal structure of M. tuberculosis DprE1 in complex with PBTZ169

Crystal structure of M. tuberculosis DprE1 in complex with PBTZ169 Descriptor: 2-(4-(cyclohexylmethyl)piperazin-1-yl)-8-nitro-6-(trifluoromethyl)-4H-benzo[e][1,3]thiazin-4-one, bound form, FLAVIN-ADENINE DINUCLEOTIDE, ... Authors: Neres, J, Pojer, F, Cole, S.T. Deposit date: 2013-10-25 Release date: 2014-02-19 Last modified: 2024-10-09 Method: X-RAY DIFFRACTION (1.881 Å) Cite: Towards a new combination therapy for tuberculosis with next generation benzothiazinones. EMBO Mol Med, 6, 2014结核分枝杆菌DprE1与PBTZ169的复合晶体结构。复合物组分描述：2-(4-(环己基甲基)哌嗪-1-基)-8-硝基-6-(三氟甲基)-4H-苯并[e][1,3]噻嗪-4-酮（结合态）、黄素腺嘌呤二核苷酸（FLAVIN-ADENINE DINUCLEOTIDE）等。作者：Neres, J、Pojer, F、Cole, S.T.。提交日期：2013-10-25；发布日期：2014-02-19；最后修改日期：2024-10-09。测试方法：X射线衍射（分辨率1.881 Å）。引用文献：《新一代苯并噻嗪酮类化合物用于结核病新型联合疗法的探索》，发表于《EMBO Mol Med》，2014年，第6卷。