RNAsequencing of the ventral rhombomere 1 of the developing mouse [bulk RNA-seq]

Sequencing of the mouse ventral rhombomere 1 tissues and cells to characterize the Tal1-dependent and -independent neuronal precursor groups. The data allowed to describe the cell types in the R1 brain region, and map gene expression dynamics during bifurcation of the GABAergic and glutamatergic lineages. Our results provide a framework for understanding the development of cellular diversity in the tegmental nuclei. Rhombomere 1 tissues were collected from 6 wild type controls and from 6 Tal1cko animals, and subjected to RNA-sequencing, in order to identify the target genes of the transcription factor Tal1.