Cells and molecules involved in local acute inflammatory response

Cells and Molecules involved in local acute inflammatory response. Pathway based on Biocarta pathway (M3952) https://cgap.nci.nih.gov/Pathways/BioCarta/h_LairPathway Tissue damage induces the release of inflammatory signaling molecules. Additionally, bacterial infection stimulates an immune response. Bacterial infection can activate macrophages and induce the release of pro-inflammatory cytokines such as TNF, IL-6 and IL-1. Both tissue damage and bacterial infection can induce complement activation, either via the alternative or classical pathway. Leukocytes can be attracted via pro-inflammatory cytokines and chemokines released by mast cells and activated macrophages. Leukocytes can also induce complement activation. The combined response can result in a more permeable endothelium of blood vessels, induce swelling and activate immune cells.

涉及局部急性炎症反应的细胞与分子。基于 Biocarta 通路（M3952）的通路分析，可访问于 https://cgap.nci.nih.gov/Pathways/BioCarta/h_LairPathway。组织损伤诱发炎症信号分子的释放。此外，细菌感染可激发免疫反应。细菌感染能够激活巨噬细胞，并诱导促炎细胞因子如 TNF、IL-6 和 IL-1 的释放。组织损伤与细菌感染均可诱导补体系统的激活，途径包括替代途径和经典途径。通过肥大细胞和活化巨噬细胞释放的促炎细胞因子和趋化因子，白细胞得以被吸引。白细胞亦能诱导补体系统的激活。这种综合反应可能导致血管内皮的通透性增加，引起水肿并激活免疫细胞。