Difluoromethylene Phosphabetaine as an Equivalent of Difluoromethyl Carbanion
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A method for nucleophilic difluoromethylation of reactive Michael acceptors, aldehydes, and azomethines is described. The reaction is performed using the readily available and air-stable reagent difluoromethylene phosphabetaine. The process involves interaction of an electrophilic substrate with in situ generated difluorinated phosphonium ylide followed by hydrolysis of the carbon–phosphorus bond under mild conditions.
创建时间：
2015-12-17
