Structure of bovine endothelial nitric oxide synthase L111A mutant heme domain in complex with 4-METHYL-6-(((3R,4R)-4-((5-(4- METHYLPYRIDIN-2-YL)PENTYL)OXY)PYRROLIDIN-3-YL)METHYL)PYRIDIN-2-AMINE

Protein Data Bank Japan2024-11-13 更新2026-03-21 收录

下载链接：

https://pdbj.org/mine/summary/4cx1

下载链接

链接失效反馈

官方服务：

资源简介：

Structure of bovine endothelial nitric oxide synthase L111A mutant heme domain in complex with 4-METHYL-6-(((3R,4R)-4-((5-(4- METHYLPYRIDIN-2-YL)PENTYL)OXY)PYRROLIDIN-3-YL)METHYL)PYRIDIN-2-AMINE Descriptor: 2-AMINO-6-(1,2-DIHYDROXY-PROPYL)-7,8-DIHYDRO-6H-PTERIDIN-4-ONE, 4-methyl-6-{[(3R,4R)-4-{[5-(4-methylpyridin-2-yl)pentyl]oxy}pyrrolidin-3-yl]methyl}pyridin-2-amine, ACETATE ION, ... Authors: Li, H, Poulos, T.L. Deposit date: 2014-04-03 Release date: 2014-08-13 Last modified: 2024-11-13 Method: X-RAY DIFFRACTION (2.13 Å) Cite: Mobility of a Conserved Tyrosine Residue Controls Isoform-Dependent Enzyme-Inhibitor Interactions in Nitric Oxide Synthases. Biochemistry, 53, 2014

牛内皮型一氧化氮合酶（bovine endothelial nitric oxide synthase）L111A突变体血红素结构域（heme domain）与4-甲基-6-(((3R,4R)-4-((5-(4-甲基吡啶-2-基)戊基)氧基)吡咯烷-3-基)甲基)吡啶-2-胺复合物的结构。配体描述：2-氨基-6-(1,2-二羟基丙基)-7,8-二氢-6H-蝶啶-4-酮、4-甲基-6-{[(3R,4R)-4-{[5-(4-甲基吡啶-2-基)戊基]氧基}吡咯烷-3-基]甲基}吡啶-2-胺、乙酸根离子（acetate ion）等。作者：Li, H、Poulos, T.L. 沉积日期：2014-04-03 发布日期：2014-08-13 最后修改日期：2024-11-13 实验方法：X射线衍射（X-ray diffraction，分辨率2.13埃（Å））引用文献：《保守酪氨酸残基的流动性调控一氧化氮合酶的同工型依赖性酶-抑制剂相互作用》，《生物化学（Biochemistry）》，第53卷，2014年

创建时间：

2014-04-03