Imbalanced Unfolded Protein Response Signaling Contributes to 1-Deoxysphingolipid Retinal Toxicity
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE213948
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资源简介：
1-deoxysphinganine accumulation is associated with retinal toxicity. We used single nucelus and bulk sequencing to profile transcriptional remodeling following treatment with 1-dexoysphnganine in human iPSC-derived retinal organoids. Human iPSC-derived retinal organoids were incubated with 1-dSA for either 2 days, 3 days or 4 days. At four days, organoids were treated with 1-dSA in the presence or absence of the ISRIB or AA147.
创建时间：
2023-07-21
