Quantification of Prohormone Processing Components in Human Dense Core Secretory Vesicles (DCSV).

The NASF values of the relative abundances for prohormone proteins and prohormone processing enzymes are listed as NASF ± S.D. (×103). The prohormone processing enzymes represent two protease pathways consisting of (1) the subtilisin-like prohormone convertases (PC1/3 and PC2) with their endogenous regulators (proSAAS and 7B2 regulators, respectively), combined with carboxypeptidase E (CPE), and the (2) cysteine protease cathepsin L pathway with aminopeptidase B (AP-B).