Crystal structure of the PDE5A1 catalytic domain in complex with novel inhibitors

Crystal structure of the PDE5A1 catalytic domain in complex with novel inhibitors Descriptor: 5-bromo-2-{5-[(4-methylpiperazin-1-yl)acetyl]-2-propoxyphenyl}-6-(propan-2-yl)pyrimidin-4(3H)-one, DI(HYDROXYETHYL)ETHER, MAGNESIUM ION, ... Authors: Ren, J, Chen, T, Xu, Y. Deposit date: 2012-12-05 Release date: 2014-01-01 Last modified: 2023-11-08 Method: X-RAY DIFFRACTION (2.08 Å) Cite: Exploration of the 5-bromopyrimidin-4(3H)-ones as potent inhibitors of PDE5. Bioorg.Med.Chem.Lett., 23, 2013本数据集记录了PDE5A1催化结构域与新型抑制剂复合的晶体结构。描述符：5-溴-2-{5-[(4-甲基哌嗪-1-基)乙酰基]-2-丙氧基苯基}-6-(异丙基)嘧啶-4(3H)-酮、二(羟乙基)醚、镁离子等。作者：Ren J、Chen T、Xu Y。提交日期：2012-12-05，发布日期：2014-01-01，最后修改日期：2023-11-08。实验方法：X射线衍射（分辨率2.08 Å）。引用文献：《探索5-溴嘧啶-4(3H)-酮类作为PDE5强效抑制剂》，《Bioorg.Med.Chem.Lett.》，2013年，第23卷。