CDK2 complex with a 4-alkynyl oxindole inhibitor

CDK2 complex with a 4-alkynyl oxindole inhibitor Descriptor: 4-((3R,4S,5R)-4-AMINO-3,5-DIHYDROXY-HEX-1-YNYL)-5-FLUORO-3-[1-(3-METHOXY-1H-PYRROL-2-YL)-METH-(Z)-YLIDENE]-1,3-DIHYDRO-INDOL-2-ONE, Cell division protein kinase 2 Authors: Luk, K.-C, Simcox, M.E, Schutt, A, Rowan, K, Thompson, T, Chen, Y, Kammlott, U, DePinto, W, Dunten, P, Dermatakis, A. Deposit date: 2003-10-20 Release date: 2004-01-20 Last modified: 2024-02-14 Method: X-RAY DIFFRACTION (2 Å) Cite: A new series of potent oxindole inhibitors of CDK2 Bioorg.Med.Chem.Lett., 14, 2004CDK2（细胞周期蛋白依赖性激酶2，Cell division protein kinase 2）与4-炔基羟吲哚抑制剂的复合物。描述项：4-((3R,4S,5R)-4-氨基-3,5-二羟基-己-1-炔基)-5-氟-3-[1-(3-甲氧基-1H-吡咯-2-基)-甲-(Z)-亚基]-1,3-二氢-吲哚-2-酮。作者：Luk, K.-C、Simcox, M.E、Schutt, A、Rowan, K、Thompson, T、Chen, Y、Kammlott, U、DePinto, W、Dunten, P、Dermatakis, A。沉积日期：2003-10-20；发布日期：2004-01-20；最后修改日期：2024-02-14。实验方法：X射线衍射（分辨率2 Å）。引用文献：一类新型强效CDK2羟吲哚抑制剂（A new series of potent oxindole inhibitors of CDK2），刊载于Bioorg.Med.Chem.Lett.，第14卷，2004年。