We report here the transcriptome analysis on resting and activated mature Treg cells from mice with conditional deletion of CARMA1 Overall design: RNA-Sequencing on CARMA1fl/fl, CARMA1fl/+ and CARMA1

NIAID Data Ecosystem20

Transcription factor Etv6 controls functional differentiation of cross-presenting classical dendritic cells [ATAC-Seq]. Transcription factor Etv6 controls functional differentiation of cross-presenting classical dendritic cells [ATAC-Seq]

树突状细胞分化

抗肿瘤免疫

An IRF8-dependent subset of classical dendritic cells (cDCs), termed DC1, effectively cross-primes CD8+ T cells and facilitates antitumor T cell responses. Etv6 is an ETS family transcription factor t

NIAID Data Ecosystem60

Interleukin-12 bypasses common gamma-chain signaling in emergency natural killer cell lymphopoiesis. Effects of IL-12 on NK cells

NK细胞发育

抗肿瘤免疫

Differentiation and homeostasis of natural killer (NK) cells relies on common gamma-chain (γc)-dependent cytokines, in particular IL-15. Consequently, NK cells do not develop in mice with targeted γc

NIAID Data Ecosystem40

Transcription factor Ikzf1 associates with Foxp3 to repress gene expression in Treg cells and limit autoimmunity and anti-tumor immunity

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