miR-517 relationship with ARCN1 and USP1

Schematic summarizing predicted miR-517a relationships with ARCN1 and USP1. A genomewide miRNA mimic toxicity screen indicates common and selective vulnerabilities of epithelial ovarian cancer cells. miR-517a targets a common vulnerability, primarily via its target ARCN1. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP3596 CPTAC Assay Portal].

图谱概要展示了预测的miR-517a与ARCN1及USP1之间的关系。全基因组miRNA模拟毒性筛选揭示了上皮性卵巢癌细胞普遍且具有选择性的脆弱性。miR-517a靶向一种共同脆弱性，主要通过其靶标ARCN1实现。该途径上的蛋白质具有针对性的检测方法，可通过[CPTAC检测门户](https://assays.cancer.gov/available_assays?wp_id=WP3596)获取。