CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 10 IN COMPLEX WITH n1(nc(nc1CCc3nn2c(nc(c2C)C)c(c3)C(F)(F)F)N4CCCC4)C, micromolar IC50=0.164550

CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 10 IN COMPLEX WITH n1(nc(nc1CCc3nn2c(nc(c2C)C)c(c3)C(F)(F)F)N4CCCC4)C, micromolar IC50=0.164550 Descriptor: (4S)-2,3-dimethyl-6-{2-[1-methyl-3-(pyrrolidin-1-yl)-1H-1,2,4-triazol-5-yl]ethyl}-7-(trifluoromethyl)imidazo[1,2-b]pyridazine, MAGNESIUM ION, ZINC ION, ... Authors: Joseph, C, Benz, J, Flohr, A, Groebke-Zbinden, K, Rudolph, M.G. Deposit date: 2022-02-01 Release date: 2022-10-12 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (2.07 Å) Cite: Crystal Structure of a human phosphodiesterase 10 complex To be published人类磷酸二酯酶10与配体n1(nc(nc1CCc3nn2c(nc(c2C)C)c(c3)C(F)(F)F)N4CCCC4)C的晶体结构，其微摩尔级半数抑制浓度（IC50）为0.164550。描述符：(4S)-2,3-二甲基-6-{2-[1-甲基-3-(吡咯烷-1-基)-1H-1,2,4-三唑-5-基]乙基}-7-(三氟甲基)咪唑并[1,2-b]哒嗪、镁离子、锌离子…… 作者：Joseph, C、Benz, J、Flohr, A、Groebke-Zbinden, K、Rudolph, M.G. 提交日期：2022-02-01；发布日期：2022-10-12；最后修改日期：2024-10-16 实验方法：X射线衍射（分辨率2.07埃） 引用文献：《人类磷酸二酯酶10复合物的晶体结构》，待发表