Solution structure of the anti-apoptotic protein Bcl-2 in complex with an acyl-sulfonamide-based ligand

Solution structure of the anti-apoptotic protein Bcl-2 in complex with an acyl-sulfonamide-based ligand Descriptor: 3-NITRO-N-{4-[2-(2-PHENYLETHYL)-1,3-BENZOTHIAZOL-5-YL]BENZOYL}-4-{[2-(PHENYLSULFANYL)ETHYL]AMINO}BENZENESULFONAMIDE, Apoptosis regulator Bcl-2 Authors: Bruncko, M, Oost, T.K, Belli, B.A, Ding, H, Joseph, M.K, Kunzer, A, Martineau, D, McClellan, W.J, Mitten, M, Ng, S.C, Nimmer, P.M, Oltersdorf, T, Park, C.M, Petros, A.M, Shoemaker, A.R, Song, X, Wang, X, Wendt, M.D, Zhang, H, Fesik, S.W, Rosenberg, S.H, Elmore, S.W. Deposit date: 2006-11-29 Release date: 2007-02-27 Last modified: 2023-12-27 Method: SOLUTION NMR Cite: Studies Leading to Potent, Dual Inhibitors of Bcl-2 and Bcl-xL. J.Med.Chem., 50, 2007与酰基磺酰胺类配体结合的抗凋亡蛋白Bcl-2的溶液结构 配体标识：3-硝基-N-{4-[2-(2-苯基乙基)-1,3-苯并噻唑-5-基]苯甲酰基}-4-{[2-(苯硫基)乙基]氨基}苯磺酰胺 该蛋白为凋亡调节蛋白Bcl-2 作者：Bruncko, M.、Oost, T.K.、Belli, B.A.、Ding, H.、Joseph, M.K.、Kunzer, A.、Martineau, D.、McClellan, W.J.、Mitten, M.、Ng, S.C.、Nimmer, P.M.、Oltersdorf, T.、Park, C.M.、Petros, A.M.、Shoemaker, A.R.、Song, X.、Wang, X.、Wendt, M.D.、Zhang, H.、Fesik, S.W.、Rosenberg, S.H.、Elmore, S.W. 存档日期：2006-11-29 发布日期：2007-02-27 最后修改日期：2023-12-27 实验方法：溶液NMR 引用文献：《强效Bcl-2与Bcl-xL双重抑制剂的相关研究》，《药物化学期刊》（J. Med. Chem.），50卷，2007年