Gene expression profiling of vein graft restenosis

Occlusive artery disease (CAD) is the leading cause of death worldwide. Bypass graft surgery remains the prevalently performed treatments for occlusive arterial disease, and veins are the most frequently used conduits for surgical revascularization. However, clinical efficacy is highly affected by the long-term potency rates of vein grafts, and no optimal treatments are available for prevention of vein graft restenosis (VGR) until today. Therefore, it is urgent to improve the understanding of molecular mechanisms involved in mediating VGR, and thereby provide potential potent therapeutic targets for prevention of vein graft failure. In this study, we aim to explore potential crucial genes and pathways associated with VGR and provide valid biological information for further investigation of VGR. A total of 16 samples were used in this study, including, 6 samples(A1,A2, A3, A4, A5, A6) that are vein grafts removed 1 day after surgery, 6 samples (C1, C2, C3, C4, C5, C6) that are vein grafts removed in 7 days after surgery group, and 4 samples (O1, O2, O3, O4) that are vein grafts obtained from sham surgery group.