CRYSTAL STRUCTURE OF A MIXTURE OF ARACHIDONIC ACID AND PROSTAGLANDIN BOUND TO THE CYCLOOXYGENASE ACTIVE SITE OF COX-2: PROSTAGLANDIN STRUCTURE

CRYSTAL STRUCTURE OF A MIXTURE OF ARACHIDONIC ACID AND PROSTAGLANDIN BOUND TO THE CYCLOOXYGENASE ACTIVE SITE OF COX-2: PROSTAGLANDIN STRUCTURE Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 7-[6-(3-HYDROPEROXY-OCT-1-ENYL)-2,3-DIOXA-BICYCLO[2.2.1]HEPT-5-YL]-HEPT-5-ENOIC ACID, ... Authors: Kiefer, J.R, Pawlitz, J.L, Moreland, K.T, Stegeman, R.A, Gierse, J.K, Stevens, A.M, Goodwin, D.C, Rowlinson, S.W, Marnett, L.J, Stallings, W.C, Kurumbail, R.G. Deposit date: 1999-11-11 Release date: 2000-05-16 Last modified: 2024-11-20 Method: X-RAY DIFFRACTION (3 Å) Cite: Structural insights into the stereochemistry of the cyclooxygenase reaction. Nature, 405, 2000结合于环氧合酶-2（COX-2）活性位点的花生四烯酸与前列腺素混合物的晶体结构：前列腺素结构 描述符：2-乙酰胺基-2-脱氧-β-D-吡喃葡萄糖（2-acetamido-2-deoxy-beta-D-glucopyranose）、2-乙酰胺基-2-脱氧-β-D-吡喃葡萄糖-(1→4)-2-乙酰胺基-2-脱氧-β-D-吡喃葡萄糖（2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose）、7-[6-(3-过氧羟基-1-辛烯基)-2,3-二氧杂双环[2.2.1]庚-5-基]-5-庚烯酸（7-[6-(3-HYDROPEROXY-OCT-1-ENYL)-2,3-DIOXA-BICYCLO[2.2.1]HEPT-5-YL]-HEPT-5-ENOIC ACID）…… 作者：Kiefer, J.R.、Pawlitz, J.L.、Moreland, K.T.、Stegeman, R.A.、Gierse, J.K.、Stevens, A.M.、Goodwin, D.C.、Rowlinson, S.W.、Marnett, L.J.、Stallings, W.C.、Kurumbail, R.G. 入库日期：1999-11-11 发布日期：2000-05-16 最后修改日期：2024-11-20 实验方法：X射线衍射（X-RAY DIFFRACTION，3 Å） 引用文献：《环氧化酶反应立体化学的结构解析》，《自然》，第405卷，2000年