Alternative Poly(A) Sites database

APASdb provides information on Alternative Poly(A) (APA) isoforms for all genes. It describes heterogeneous cleavage sites downstream of poly(A) signals, and maintains near complete coverage for APA sites. APASdb provides the quantification of a given APA variant among transcripts with different APA sites by computing their corresponding normalized-reads. In addition, APASdb supports URL-based retrieval, browsing and display of exon-intron structure, poly(A) signals, poly(A) sites location and usage reads, and 3'-untranslated regions (3'-UTRs). Currently, APASdb involves APA in various biological processes and diseases in human, mouse and zebrafish.

APASdb提供所有基因的可变聚腺苷酸化（Alternative Poly(A), APA）异构体信息。该数据库描述了聚腺苷酸化信号下游的异质性切割位点，并实现了对可变聚腺苷酸化位点的近乎全覆盖。APASdb通过计算对应归一化读段，定量分析携带不同可变聚腺苷酸化位点的转录本中特定APA变体的占比。此外，APASdb支持基于URL的检索、浏览，以及外显子-内含子结构、聚腺苷酸化信号、聚腺苷酸化位点位置与使用读段、3'非翻译区（3'-UTRs）的展示。目前，APASdb收录了人类、小鼠及斑马鱼中参与多种生物学过程与疾病的可变聚腺苷酸化事件。