2.1 Angstrom structure of a nonproductive complex between antithrombin, synthetic heparin mimetic SR123781 and two S195A thrombin molecules
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2.1 Angstrom structure of a nonproductive complex between antithrombin, synthetic heparin mimetic SR123781 and two S195A thrombin molecules Descriptor: 2,3,4,6-tetra-O-sulfonato-alpha-D-glucopyranose-(1-4)-2,3,6-tri-O-sulfo-alpha-D-glucopyranose-(1-4)-2,3,6-tri-O-sulfonato-beta-D-glucopyranose-(1-4)-2,3-di-O-methyl-6-O-sulfonato-alpha-D-glucopyranose-(1-4)-2,3,6-tri-O-methyl-beta-D-glucopyranose-(1-4)-2,3,6-tri-O-methyl-alpha-D-glucopyranose-(1-4)-2,3,6-tri-O-methyl-beta-D-glucopyranose-(1-4)-2,3,6-tri-O-methyl-alpha-D-glucopyranose-(1-4)-2,3,6-tri-O-methyl-beta-D-glucopyranose-(1-4)-2,3,6-tri-O-methyl-alpha-D-glucopyranose-(1-4)-2,3,6-tri-O-methyl-beta-D-glucopyranose-(1-4)-2,3-di-O-methyl-6-O-sulfonato-alpha-D-glucopyranose-(1-4)-2,3-di-O-methyl-beta-D-glucopyranuronic acid-(1-4)-2,3,6-tri-O-sulfo-alpha-D-glucopyranose-(1-4)-2,3-di-O-methyl-alpha-L-idopyranuronic acid-(1-4)-methyl 3-O-methyl-2,6-di-O-sulfo-alpha-D-glucopyranoside, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Johnson, D.J, Li, W, Luis, S.A, Carrell, R.W, Huntington, J.A. Deposit date: 2005-09-29 Release date: 2006-09-19 Last modified: 2024-11-13 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Crystal structure of monomeric native antithrombin reveals a novel reactive center loop conformation. J.Biol.Chem., 281, 2006
2.1埃分辨率的抗凝血酶（antithrombin）、合成肝素模拟物SR123781与两个S195A突变型凝血酶（thrombin）分子之间的非活性复合物的晶体结构 描述符：2,3,4,6-四-O-磺酰基-α-D-吡喃葡萄糖-(1→4)-2,3,6-三-O-磺酰基-α-D-吡喃葡萄糖-(1→4)-2,3,6-三-O-磺酰基-β-D-吡喃葡萄糖-(1→4)-2,3-二-O-甲基-6-O-磺酰基-α-D-吡喃葡萄糖-(1→4)-2,3,6-三-O-甲基-β-D-吡喃葡萄糖-(1→4)-2,3,6-三-O-甲基-α-D-吡喃葡萄糖-(1→4)-2,3,6-三-O-甲基-β-D-吡喃葡萄糖-(1→4)-2,3,6-三-O-甲基-α-D-吡喃葡萄糖-(1→4)-2,3,6-三-O-甲基-β-D-吡喃葡萄糖-(1→4)-2,3,6-三-O-甲基-α-D-吡喃葡萄糖-(1→4)-2,3,6-三-O-甲基-β-D-吡喃葡萄糖-(1→4)-2,3-二-O-甲基-6-O-磺酰基-α-D-吡喃葡萄糖-(1→4)-2,3-二-O-甲基-β-D-吡喃葡萄糖醛酸-(1→4)-2,3,6-三-O-磺酰基-α-D-吡喃葡萄糖-(1→4)-2,3-二-O-甲基-α-L-艾杜吡喃糖醛酸-(1→4)-3-O-甲基-2,6-二-O-磺酰基-α-D-吡喃葡萄糖苷甲酯，2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖，2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖-(1→4)-2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖…… 作者：Johnson, D.J.、Li, W.、Luis, S.A.、Carrell, R.W.、Huntington, J.A. 提交日期：2005年9月29日 发布日期：2006年9月19日 最后修改日期：2024年11月13日 实验方法：X射线衍射（X-RAY DIFFRACTION，2.1埃） 引用文献：单体天然抗凝血酶的晶体结构揭示了一种新型反应中心环构象。《生物化学杂志（J.Biol.Chem.）》，281卷，2006年
