The 10 best and 10 worst combinations of orthobiologic factors, as determined from the best-generalizing ANN (Fig 1).

Combinations are ranked, best to worst, out of the total of 2400 combinations in the computational screen. BMP2 and BMP7 are at their highest levels in the 10 best combinations, while they are 0 in the 10 worst combinations. OG tends to be at its highest or lowest levels in the 10 best or worst, respectively, while PDGF tends in the opposite direction. The 10 best and worst combinations seem indifferent to the level of PU. ES or BMAC is present in some of the 10 best but in none of the 10 worst. PRP is absent from all 10 best and worst combinations. EGB is present in them all but it is present in all 2400 combinations by design and is included only for completeness. Units: BMP2 and BMP7 are in milligrams, OG and PDGF are in micrograms, and PU is in total treatment days; the other inputs are either present or absent. The levels (dosages, intensities, amounts, etc) of all inputs are in the ranges as reported in published studies (see S1 Text and S1 Dataset).