ChIP-seq analysis of HIF-1a capacity to bind the promoters of its target genes on wt vs. PARP-1 K.O. cells

Comparison of the HIF-1a DNA binding profile after 4 hours of hypoxia 1% on HEK293T PARP-1 K.O. CELLS vs. HEK293T WT cells after 4 hours of hypoxia 1%. Overall design: Examination of HIF-1a hypoxic-induced binding to the DNA in 2 cell types.