Tumor Microenvironment Profiling Identifies Prognostic Signatures and Suggests Immunotherapeutic Benefits in Neuroblastoma
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE182586
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Here, we profiled the TME landscape of 498 NB patients on a self-curated gene list and identified 3 prognostic TMEsubgroups. Differentially expressed genes (DEGs) among 3 TMEsubgroups constructed a genetic background of the TME landscape and characterized 3 GeneSubgroups. We further created a 48-gene signature, the TMEscore, to infer prognosis and validated in 3 independent NB cohorts and a pan-cancer cohort of 9460 patients. We did RNA-seq on 16 samples and verified that TMEscore was higher in stage 3/4 patients. RNA-seq of 10 stage 1/2 and 6 stage 3/4 neuroblastoma samples
创建时间：
2022-05-05
