Purkinje Cell Dendritic Defects in Bcl-w−/−Grid2ho−4J(−/−) Mice.

Purkinje cell dendritic abnormalities in Bcl-w−/−Grid2 ho−4J(−/−) mice were quantified using the Strahler system of topological analysis on Golgi-stained Purkinje cells. The number of the dendritic branches in each Strahler order was counted for several Purkinje cells for wild type, single knockout, and double knockout mice. Statistic analysis was performed between two genotypes of mice in each order using student t-test. Purkinje cells in Bcl-w−/−Grid2ho−4J(−/−) mice are significantly different from all other genotypes in every Strahler order (p†, *, ‡ Indicate the significant difference (pBcl-w−/− and Grid2ho−4J(−/−) mice.