Crystal structure of human PI3K-gamma in complex with pyridinylquinoline inhibitor N-{(1S)-1-[8-chloro-2-(2-methylpyridin-3-yl)quinolin-3-yl]ethyl}-9H-purin-6-amine

Crystal structure of human PI3K-gamma in complex with pyridinylquinoline inhibitor N-{(1S)-1-[8-chloro-2-(2-methylpyridin-3-yl)quinolin-3-yl]ethyl}-9H-purin-6-amine Descriptor: GLYCEROL, N-{(1S)-1-[8-chloro-2-(2-methylpyridin-3-yl)quinolin-3-yl]ethyl}-9H-purin-6-amine, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, ... Authors: Whittington, D.A, Tang, J, Yakowec, P. Deposit date: 2014-11-11 Release date: 2014-12-17 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Discovery and in Vivo Evaluation of (S)-N-(1-(7-Fluoro-2-(pyridin-2-yl)quinolin-3-yl)ethyl)-9H-purin-6-amine (AMG319) and Related PI3K delta Inhibitors for Inflammation and Autoimmune Disease. J.Med.Chem., 58, 2015

人类磷脂酰肌醇3-激酶γ（PI3K-gamma）与吡啶并喹啉类抑制剂N-{(1S)-1-[8-氯-2-(2-甲基吡啶-3-基)喹啉-3-基]乙基}-9H-嘌呤-6-胺的复合物晶体结构
描述项：甘油、N-{(1S)-1-[8-氯-2-(2-甲基吡啶-3-基)喹啉-3-基]乙基}-9H-嘌呤-6-胺、磷脂酰肌醇4,5-二磷酸3-激酶催化亚基γ亚型……
作者：Whittington, D.A、Tang, J、Yakowec, P.
提交日期：2014-11-11
发布日期：2014-12-17
最后修改日期：2024-02-28
实验方法：X射线衍射（2.4 Å）
引用文献：《(S)-N-(1-(7-氟-2-(吡啶-2-基)喹啉-3-基)乙基)-9H-嘌呤-6-胺（AMG319）及相关PI3Kδ抑制剂的发现与体内评价：用于炎症与自身免疫性疾病》，J.Med.Chem., 58, 2015