Stearoyl-CoA desaturase 1 (SCD1) catalyzes the rate limiting step in monounsaturated fatty acid synthesis by inserting a double bond at the delta-9 position of long-chain fatty acids. SCD1 converts st

NIAID Data Ecosystem60

The Xenobiotic Transporter Mdr1 Enforces T Cell Homeostasis in the Presence of Intestinal Bile Acids [shMdr1 RNA-seq in vivo]

肠道T细胞稳态

胆汁酸代谢

CD4+ T cells are tightly regulated by microbiota in the intestine, but whether intestinal T cells interface with host-derived metabolites is less clear. Here, we show that CD4+ T effector (Teff) cells

NIAID Data Ecosystem30

Oral exposure to benzalkonium chlorides in male and female mice reveals sex-dependent alteration of the gut microbiome and bile acid profile

微生物群

胆汁酸代谢

Benzalkonium chlorides (BACs) are commonly used disinfectants in a variety of consumer and food-processing settings, and the COVID-19 pandemic has led to increased usage of BACs. The prevalence of BAC

DataONE2024-04-23 更新100

Sequencing the cecal microbiota of cholic acid-fed WKAH/HkmSlc rats. rat gut metagenome

微生物组

胆汁酸代谢

Bile acid has recently revealed to be a host factor that regulates gut microbiota in rats. Physiologically-relevant concentration of cholic-acid, a representative primary bile acid in human, was fed t

NIAID Data Ecosystem50

gut metagenome Raw sequence reads

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