Crystal structure of 17alpha-hydroxysteroid dehydrogenase mutant K31A in complex with NADP+ and epi-testosterone

Crystal structure of 17alpha-hydroxysteroid dehydrogenase mutant K31A in complex with NADP+ and epi-testosterone Descriptor: (10ALPHA,13ALPHA,14BETA,17ALPHA)-17-HYDROXYANDROST-4-EN-3-ONE, 1,2-ETHANEDIOL, 3(17)alpha-hydroxysteroid dehydrogenase, ... Authors: Faucher, F, Cantin, L, Pereira de Jesus-Tran, K, Lemieux, M, Luu-the, V, Labrie, F, Breton, R. Deposit date: 2006-10-12 Release date: 2007-06-19 Last modified: 2023-08-30 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Mouse 17alpha-Hydroxysteroid Dehydrogenase (AKR1C21) Binds Steroids Differently from other Aldo-keto Reductases: Identification and Characterization of Amino Acid Residues Critical for Substrate Binding. J.Mol.Biol., 369, 2007本数据集为结合烟酰胺腺嘌呤二核苷酸磷酸（NADP+）与表睾酮的17α-羟类固醇脱氢酶（17alpha-hydroxysteroid dehydrogenase）K31A突变体的晶体结构。相关描述项包括：(10α,13α,14β,17α)-17-羟基雄甾-4-烯-3-酮、1,2-乙二醇、3(17)α-羟类固醇脱氢酶等。作者：Faucher F、Cantin L、Pereira de Jesus-Tran K、Lemieux M、Luu-the V、Labrie F、Breton R。沉积日期：2006年10月12日；发布日期：2007年6月19日；最后修改日期：2023年8月30日。实验方法：X射线衍射（1.9埃）。引用文献：《小鼠17α-羟类固醇脱氢酶（AKR1C21）与其他醛酮还原酶的类固醇结合模式存在差异：底物结合关键氨基酸残基的鉴定与表征》，发表于《分子生物学杂志》（J.Mol.Biol.）2007年第369卷。