PI3K-AKT-mTOR signaling and therapeutic opportunities in prostate cancer

This pathway is based on figure 1 from Merritt et al. (See Bibliography). The PI3K-AKT-mTOR signaling pathway has been shown to have a significant correlation with the development of castration-resistant prostate cancer. The signaling pathway regulates many cellular processes such as protein synthesis, proliferation, survival, metabolism, and differentiation, all factors that would increase a cancerous cell's ability to survive. Scientists have explored the use of various inhibitors for different parts of the signaling pathway, and have been faced with varying success. Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP3844 CPTAC Assay Portal]

本路径基于Merritt等人（参见参考文献）图1。PI3K-AKT-mTOR信号通路已被证明与去势抵抗性前列腺癌的发生发展具有显著相关性。该信号通路调节多种细胞过程，如蛋白质合成、增殖、存活、代谢和分化，所有这些因素均能增强癌细胞生存的能力。科学家们已探索了针对信号通路不同部分的多种抑制剂的使用，并遭遇了不同的成功。该通路上的蛋白质已可通过[https://assays.cancer.gov/available_assays?wp_id=WP3844 CPTAC检测门户网站]提供的相关检测进行靶向分析。