Transmission of Alzheimers Disease-Associated Microbiota Dysbiosis and its Impact on Cognitive Function: Evidence from Mice and Patients

Spouses of Alzheimers disease (AD) patients are at a higher risk of developing incidental dementia. However, the causes and underlying mechanism of this clinical observation remain largely unknown. One possible explanation is linked to microbiota dysbiosis, a condition that has been associated with AD. We set out to perform both animal studies and clinical investigation by co-housing wild-type mice and AD transgenic mice, analyzing microbiota via 16S rRNA gene sequencing, measuring short chain fatty acid amounts, and employing behavioral test, mass spectrometry, site-mutations and other methods.