Differential gene expression in proliferating GC-Tfh cells from HIV-infected and HIV-uninfected LNs.

We used single-gene analysis to determine the pattern of gene expression in proliferating LN GC-Tfh cells in co-culture with autologous GC-B cells from HIVpos patients versus HIVneg subjects. We generated heatmaps of the top 100 DEGs in proliferating (CFSEneg vs CFSEpos) HIVneg and HIVpos GC-Tfh cells compared to non-dividing cells (Fig 3B and 3C). This Table comprises all top 100 DEGs shown in the heatmaps with their log2-fold changes (logFC) as well as nominal p-values. The first sheet displays the top upregulated and downregulated DEGs in proliferating HIVneg GC-Tfh cells, whereas the second sheet displays the top upregulated and downregulated DEGs in proliferating HIVpos GC-Tfh cells. The included DEGs have the highest positive or negative logFC and statistically significant nominal p-values of <0.05.
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