Immunohistochemical analysis of SRPK1 and SRPK2 proteins expression in non-small cell lung cancer according to histological subtype.

Abbreviations: ADC, adenocarcinoma; SCC, squamous cell carcinoma; NSCLC, non-small cell lung carcinoma. Immunostaining scores were calculated by multiplying the number of labeled cells (0–100%) by the level of intensity (1–3). According to this, tumor samples were grouped into three classes (see ‘Materials and Methods’ section): class 0 (normal expression, as compared to normal lung), class 1 (moderate overexpression) and class 2 (high overexpression). Statistical analysis was done using Fisher’s exact test.