Global microRNAs and isomiRs expression associated with liver metabolism in male Chinese rare minnow (Gobiocypris rarus) induced by organophosphorus flame retardants Exposure

To reveal the adverse effects of organophosphorus flame retardants (OPFRs) on aquatic organisms from the perspective of epigenetic, male Chinese rare minnow were exposed to 0.24 mg/L tris(2-butoxyethyl) phosphate (TBEP), 0.04 mg/L tris(1,3-dichloro-2-propyl) phosphate (TDCIPP), and 0.012 mg/L triphenyl phosphate (TPHP) for 14 days. Effects of sub-chronic exposure to OPFRs to the liver miRNAs and 3’ isomiRs expression profiles of Chinese rare minnow were investigated.