A Whole Transcriptome Profiling of Uterine Leiomyoma Cells under the influence of Phenolic Environmental Estrogen

The study aimed to recognize potential molecular targets and signal pathways whereby phenolic environmental estrogen promotes the proliferation of uterine leiomyoma cells.Primary cultured cell lines were treated with 0.1%DMSO,10.0 umol/L BPA, and 32.0 umol/L NP for 48 h before RNA-seq was performed. Differentially expressed genes affected by BPA and NP were selected. The results indicated that Phenolic environmental estrogens may promote the proliferation and cell cycle progression of uterine leiomyoma cells through rapid non-genomic ER signaling, which leads to disordered cell cycle regulation and accelerates the transition of the cell cycle from G0/G1 phase to S phase. In addition, as an external harmful stimulant, phenolic estrogen promotes the upregulation of inflammatory factors in uterine leiomyomas.