Proteome-wide profiling of Transcriptional Machinery on Accessible Chromatin with biotinylated transposons [ATAC-seq]

This study introduced a method for directly identifying the transcriptional machinery on accessible chromatin (ATAC-MS) in a proteome scale. The goals of this study are to integrate ATAC-seq with ATAC-MS to investigate the real-time in vivo transcriptional regulatory processes in organisms. ATAC-seq was applied to identify changes in chromatin accessibility and transcription factors binding motifs in different cells.