Results of genome-wide, follow-up and combined association studies.

aQuantitative measure (abbreviation): serum ferritin concentration (SF), transferrin saturation (TfS), serum transferrin receptor (sTfR), total iron-binding capacity (TIBC), unsaturated iron-binding capacity (UIBC).bFor analysis of the GWAS genotype data, the regression models for all outcomes included the additive genotype term and the covariates, age, sex and a five-level factor indicating the center where the sample was collected. For analysis of the follow-up genotype data, the regression models for all outcomes included the additive genotype term and the covariates, age and sex.cFor case-control analyses only, the odds ratios estimate the odds in favor of being iron deficient (over being iron replete) among those participants who have one additional minor allele, divided by the odds of being iron deficient among those without the additional minor allele. For all other outcomes, a positive linear regression coefficient indicates that increasing values of the quantitative outcome are associated with increasing copies of the minor allele in the genotype.