CXCR4
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https://rgd.mcw.edu/rgdweb/report/gene/main.html?id=732176
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资源简介：
This gene encodes a CXC chemokine receptor specific for stromal cell-derived factor-1. The protein has 7 transmembrane regions and is located on the cell surface. It acts with the CD4 protein to support HIV entry into cells and is also highly expressed in breast cancer cells. Mutations in this gene have been associated with WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
本基因编码一种针对间质细胞衍生因子-1的CXC趋化因子受体。该蛋白含有7个跨膜区域，位于细胞表面。它与CD4蛋白协同作用，支持人类免疫缺陷病毒进入细胞，并在乳腺癌细胞中高表达。该基因中的突变与WHIM（疣、低丙种球蛋白血症、感染和骨髓外渗）综合征相关。已鉴定出不同的转录剪接变体，它们编码不同的异构体。[由RefSeq提供，2008年7月]
提供机构：
Rat Genome Database
