Ether lipid biosynthesis

Ether lipid biosynthesis in humans. Ether lipids (e.g. plasmalogens), are peroxisome-derived glycerophospholipids where the hydrocarbon chain at the sn-1 position of the glycerol backbone is attached by an ether bond (single bond between carbon and oxygen atom). Ether lipids are used to form non-lamellar inverted hexagonal structures in model membranes (indicating they could facilitate membrane fusion processes). Lipid raft microdomains (cholesterol-rich membrane regions involved in cellular signaling) rely on ether lipids for their organization and stability. [PMID:28523433]. The pathway knowledge depicted in this model stems from Robert C. Murphy, who endorsed version r123734. Metabolic conversion missing an identifier from Rhea have been visualized with double line thickness.

人类醚脂生物合成。醚脂（例如，磷脂酰乙醇胺），是源自过氧化物酶体的甘油磷脂，其中甘油骨架sn-1位点的烃链通过醚键（碳原子与氧原子之间的单键）连接。醚脂被用于在模型膜中形成非层状反六角结构（表明它们可能促进膜融合过程）。脂质筏微区（富含胆固醇的细胞信号传导相关膜区域）依赖于醚脂的组织和稳定性。[PMID:28523433]。本模型中展示的通路知识源于Robert C. Murphy，其认可版本为r123734。Rhea中缺少标识符的代谢转化已用双线厚度进行可视化。