Modulation of soluble receptor for advanced glycation end products isoforms and advanced glycation end products in long-living individuals

This record contains raw data related to the article "Modulation of soluble receptor for advanced glycation end products isoforms and advanced glycation end products in long-living individuals" <strong>Background:</strong> Circulating levels of soluble receptor for advanced glycation end products (sRAGE) and advanced glycation end products (AGEs) correlate with aging/cardiovascular risk, which is delayed in long-living individuals (LLIs). AGEs/sRAGE isoforms (cleaved RAGE [cRAGE] and secretory RAGE [esRAGE]) ratio is a valuable marker for disease risk. <strong>Results:</strong> We evaluated circulating sRAGE isoforms, and AGEs in LLIs (n = 95; 90-105 years) and controls (n = 94; 11-89 years). cRAGE decreased with age in controls and further declined in LLIs. esRAGE increased in LLIs. AGEs rose with age in controls and decreased in LLIs that were characterized by a lower AGEs/sRAGE ratio. Notably, cRAGE and AGE/esRAGE ratio better discriminated controls from LLIs. <strong>Conclusion:</strong> circulating cRAGE could be considered a reliable marker of chronological age while esRAGE a protective factor for longevity.