Regioselective Iodoazidation of Alkynes: Synthesis of α,α-Diazidoketones

Aryl alkyl alkynes reacted with N-iodosuccinimide
(NIS) and trimethylsilyl azide (TMSN3), leading to α,α-diazidoketones
via the regioselective addition of IN3 to alkynes. Huisgen
cyclization of α,α-diazidoketones generated bis-triazole
compounds.

芳基烷基炔与N-碘代琥珀酰亚胺（NIS）及三甲基硅基叠氮化物（TMSN3）反应，通过IN3对炔的位选择性加成，生成α,α-叠氮二酮。α,α-叠氮二酮的Huisgen环化反应产生了双三唑化合物。