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The phosphorylation of the Smad2/3 linker region by Nemo-like kinase regulates TGF-β signaling

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NIAID Data Ecosystem2026-03-12 收录
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Smad2 and Smad3 (Smad2/3) primarily mediates the transforming growth factor-β (TGF-β) signaling that drives cell proliferation, differentiation, and migration. The dynamics of the Smad2/3 phosphorylation provides the key mechanism for regulating the TGF-β signaling pathway. Here we identified NLK as a novel regulator of TGF-β signaling pathway via modulating the phosphorylation of Smad2/3 in the linker region.

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2021-09-10
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