Gene expression in rhesus monkey vastus lateralis muscle in response to long-term calorie restriction

The effect of a long-term calorie restricted diet was evaluated in vastus lateralis muscle of rhesus monkeys For biopsy collection, the animals were given buprenorphine (0.01-0.03 mg/kg, IM) in the morning immediately preceding all biopsies and again that afternoon At the time of tissue collection, control animals (27-30 years old) and CR animals (27-32 years old) had been subjected to CR for 18.5 years (n=5 control and n=8 CR monkeys per group);